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doi:10.1017/s1463423619000227 Alpert JS

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Have previously attempted weight loss without long-term success

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Less Common but Serious Risks Most reported tirzepatide side effects are digestive and may be manageable, but the medication also carries serious warnings that patients should understand

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[7] Two trials in the phase 3 TRIUMPH program reached primary completion in April 2026: TRIUMPH-1, a master protocol in adults with obesity or overweight, and TRIUMPH-3, in participants with severe obesity and established cardiovascular disease

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