Inhibiting DPP-4 enzyme activity The enzyme dipeptidyl peptidase-4 (DPP-4) rapidly breaks down natural GLP-1, giving it a half-life of only 1-2 minutes
The US Food and Drug Administration (FDA) has approved liraglutide (3.0 mg, daily) and subcutaneous semaglutide (2.4 mg, weekly) for weight management, which are irregular doses for diabetic control
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Study: Increase in circulating GLP-1 following low FODMAP diet in irritable bowel syndrome patients
But right now, there are no data that Im aware of supporting that this is a problem, Klein said.