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This condition occurs when melanocytes, the specialized cells responsible for producing melanin pigment, become overactive and generate excessive amounts of melanin in localized areas of the skin

Murine studies also showed that GLP-1 RA might be protective against renal oxidative stress by inhibition of NAD(P)H oxidase and by activation of the cAMP-protein kinase A pathway [48]

Safety signals were manageable, with cytokine release syndrome reported in 56% of participants, predominantly mild (grades 12), and only rare severe cases

Roger: Thank you so much