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Yes, semaglutide can be used if you dont have diabetes when prescribed as Wegovy for weight loss
Mechanism of Action: Nauck & D'Alessio (2022) - "Tirzepatide, a dual GIP/GLP-1 receptor co-agonist for the treatment of type 2 diabetes with unmatched effectiveness regarding glycaemic control and body weight reduction." Molecular Metabolism
Notably, among all classes of antidiabetic drugs, GLP-1RAs, a form of incretin (INtestinal secretion of INsulin) hormone-based therapy, offer additional advantages, such as inducing weight loss and preventing hypoglycemia symptoms
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However, exposure to high glucose conditions did increase mRNA expression and membrane-bound DPP-4 activity in human glomerular (76) and dermal (77) microvascular endothelial cells in vitro , although, interestingly, not in macrovascular (human aortic) endothelial cells (77)
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