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Novo Nordisk held 59.60% of the global branded GLP-1 obesity market by volume in 2025, which kept it in the leading position across brand recognition, clinical evidence, and supply chain scale inside the semaglutide weight management drug market

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Also, although there was a trend toward lower muscle cell fats when combining the NNMT-inhibiting compound with exercise, the decline was not significant

Because of this, doctors sometimes prescribe them off-label to support weight management when appropriate