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In reality, starting high increases side effects, makes it impossible to identify your true minimum effective dose, and may actually reduce effectiveness if receptor downregulation occurs

In an article published by Eureka Health, Sina Hartung, of Harvard Medical School, offered some tips that can amplify the medication's effect and allow people to lock into successful long-term maintenance

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LNCaP-AR and LN95-AR cells exhibited enhanced suppression of MYC by SPA (Figure 5H and Supplemental Figure 12A), followed by extensive vacuolization (Supplemental Figure 13) and cell death, not resistance (Figure 5I and Supplemental Figure 12B)