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But, heres what can help How to Lose Weight & Keep It Off Convincing evidence shows lifestyle intervention is key for sustained weight loss

However, indirect factors such as nutritional deficiencies from rapid weight loss may contribute to RLS symptoms in some patients

While GLP-1 agonists produce dramatic results for many patients, a meaningful subset achieves suboptimal weight loss or experiences diminishing efficacy over time

Understanding the complete duration of semaglutide treatment helps frame these decisions within a realistic timeline rather than reacting to temporary side effects

Supplementary material The Supplementary Material for this article can be found online at: Abbreviations AE-PCOS, Androgen Excess and PCOS Society