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CNS tissue has an exceptional ability to take up glutamate via excitatory amino acid transporters (EAATs), leading to a high level of substrate readily available to be converted to -KG (and subsequently 2-HG, with its potential for downstream tumorigenic effects.) This may explain why IDH1 mutations are highly prevalent in many CNS malignancies like GBM and could play an important role in tumor progression
doi: 10.1038/s41598-022-25908-6 180 BoufidouFMediSLampropoulouVSiafakasNTsakrisAAnastassopoulouC
Target sequence polymorphism of human manganese superoxide dismutase gene and its association with cancer risk: a review
You may also enjoy reading our blog on MOTS-c Explained: How This Peptide Supports Energy, Metabolism, and Healthy Aging, which explores one of the most promising mitochondrial peptides in longevity science
It is also believed to contribute to better physical performance by enhancing oxygen delivery to muscles, reducing muscle fatigue, improving muscle strength and endurance, and speeding up muscle recovery after workouts
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