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Of the 1822 participants on a GLP-1 RA, 72% (1309 individuals) were still on therapy for at least 3 years
Supported by: Novo Nordisk (NNF23OC0082732), Folkhlsan Fnd, Stockmann Fnd, Academy of Finland, Juselius Fnd, Liv och Hlsa Soc, Med
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Research published in JCI Insight describes tirzepatide as an "imbalanced and biased" dual agonist, meaning it shows equal affinity for the GIP receptor compared to native GIP but approximately 5-fold weaker affinity for the GLP-1 receptor compared to native GLP-1
It incorporates amino acid substitutions relative to the native sequence that increase resistance to enzymatic degradation, but the precise positional changes that distinguish the published afamelanotide sequence from native alpha-MSH should be verified against the primary medicinal chemistry literature (Hruby et al., University of Arizona) rather than taken from secondary sources
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