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When a cell over-expresses NNMT, it does two costly things at once: it burns through methyl-donor capacity, and it diverts nicotinamide away from NAD+ regeneration into an inert metabolite (1-methylnicotinamide) that gets excreted
BPC-157 upregulates vascular endothelial growth factor (VEGF), driving angiogenesis at the injury site (Sikiric et al., Curr Pharm Des, 2018)
Importantly, lapaquistat treatment of HCT-8 cells increased ROS within HCT-8 cells, while NB-598 which causes a squalene build-up reduced ROS levels (Fig 3G)
Most side effects from B12 shots resolve quickly, making them generally well-tolerated for routine supplementation
Molitch ME, Clemmons DR, Malozowski S, Merriam GR, Vance ML
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