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Both the European Medicines Agency and the World Health Organization last year issued product alerts for semaglutide and a potential increased risk of NAION

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In late August 2015, the US FDA issued a warning that drugs like sitagliptin, saxagliptin, linagliptin, alogliptin, and other DPP-4 inhibitors could cause joint pain that can be severe and disabling

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Its use is limited to analytical investigation, cellular process studies, and redox-related biochemical research conducted under structured experimental protocols