pancreatitis with glp 1 PSCs and GLP-1R: occurrence in normal pancreas, acute/chronic and effect of their activation by a GLP-1R agonist Updates in Medicine | GLP-1s

Presented for research literature review only Testa C et al

Melanotan 1: mechanisms of action, clinical applications and safety Dec 82023 General Description Melanotan 1 is a synthetic analogue of the hormone alpha-melanocyte stimulating hormone (-MSH) and is primarily used for its tanning effects and potential treatment of skin conditions

These digestive symptoms are amongst the most commonly reported issues with GLP-1 receptor agonist injections, particularly during the initial weeks of treatment or after dose increases

The SGLT2i treated cohort experienced higher rates of diabetic ketoacidosis (DKA) (RR 2.08 [95% CI 1.05, 4.12] p =0.0309) and urinary tract infection/pyelonephritis (RR 2.27 [95% CI 1.12, 4.55] p =0.019) compared with the GLP-1 RA treated cohort

Every dose group in the Phase 2 trial started at 2 mg