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A meta-analysis of 26 RCTs (n=3,864) found that NAC (typically 600 mg twice daily) reduced the incidence of contrast-induced nephropathy by 40% (OR 0.60, 95% CI 0.44-0.81) (Gonzales et al., BMC Med, 2007) [67]

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Yet, as the field seeks to move from detection toward intervention, the central challenge becomes how these biomarkers can reliably inform the design, assessment, and validation of neuroprotective therapies

Because subtle molecular degradation is not always visible to the eye, adhering strictly to documented storage windows is the most reliable safeguard