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They reflect the known contraindications for GLP-1 and GIP receptor agonists based on clinical trial data and FDA labeling for the brand-name equivalents

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Additionally, GLP-1 receptor agonists slow gastric emptying , which prolongs the feeling of fullness after meals and helps regulate post-meal blood glucose spikes

It has protective features on the -cells survival, and this has a synergistic effect with GLP-1 in healthy humans, but this mechanism is impaired in those with T2DM [21,22]

Dietary changes: Small sips of fluids Sip water regularly rather than drinking large amounts at once