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Mouse models of progeria have been developed to study disease progression and have also been adapted to study premature aging [12,165]
This dosing regimen produced measurable senescent cell clearance and functional improvements including enhanced physical activity, improved kidney function markers, and restored fur quality
The connecting theme across these observations is tissue repair and protection, particularly in contexts of mucosal, vascular, muscular, and tendinous injury
In animal models, BPC-157 has demonstrated the ability to enhance fibroblast activitythe cells accountable for collagen synthesisand to optimize the organization of collagen fibers during tissue repair
doi:10.1038/s41392-025-02176-0 52
