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Composed of glycine, histidine, and lysine combined with a copper ion, this peptide is naturally found in human plasma, saliva, and urine, though its levels decline with age
However, extant human studies on BPC-157 as an anti-ulcer agent indicate a positive safety profile, with no toxicity reported [34]
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Specifically, the enzyme histamine-N-methyltransferase (HNMT) uses methyl groups provided by S-adenosylmethionine (SAMe) which is regenerated through methylation to convert histamine into inactive N-methylhistamine
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