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TRPV1 antagonists that cause hypothermia, instead of hyperthermia, in rodents: compounds pharmacological profiles, in vivo targets, thermoeffectors recruited and implications for drug development

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For patients with Graves disease specifically, several factors influence the decision to prescribe Saxenda: Current thyroid status : Patients should have well-controlled thyroid function before initiating weight management therapy Treatment stability : Those on antithyroid medications or post-treatment (radioactive iodine or surgery) with stable thyroid hormone levels are generally suitable candidates Concurrent medications : Potential interactions with thyroid medications should be considered Individual risk-benefit assessment : The clinical need for weight loss must be weighed against any theoretical risks Patients with uncontrolled hyperthyroidism should not commence Saxenda until their thyroid function is optimised, as the metabolic effects of excess thyroid hormone can complicate weight management and increase cardiovascular risks

Mishra, A

Felson DT, Lawrence RC, Dieppe PA, Hirsch R, Helmick CG, Jordan JM, Kington RS, Lane NE, Nevitt MC, Zhang Y, Sowers M, McAlindon T, Spector TD, Poole AR, Yanovski SZ, Ateshian G, Sharma L, Buckwalter JA, Brandt KD, Fries JF (2000) Osteoarthritis: new insights