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Evidence level Mouse and cell studies only
Anagnostis P, Christou K, Artzouchaltzi AM, Gkekas NK, Kosmidou N, Siolos P, et al
Nuclear receptor pathway The core innovation of TPD targeting the nuclear receptor pathway lies in the integration of a trifunctional structure comprising an MDM2-binding domainCRBN ligandnuclear receptor ligand unit, which combines the direct degradation activity of classical PROTACs with nuclear receptor-mediated transcriptional regulatory functions [81]
Up-regulation of mmp-2 by histone h3k9 beta-hydroxybutyrylation to antagonize glomerulosclerosis in diabetic rat
Reduced apoptosis is often associated with the development of cancer, and finding agents that can restore programmed cell death in cancer cells is considered a potential therapy for cancer
