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Lipoic acid might be able to increase glutathione synthesis in aged rats by up-regulating the expression of -glutamylcysteine ligase (-GCL), the rate-limiting enzyme in glutathione synthesis (31), and by increasing cellular uptake of cysteine, an amino acid required for glutathione synthesis (32)
In Drosophila melanogaster , the peptide reduced mitochondrial and cytosolic ROS levels, along with lipid peroxidation markers such as Schiff bases and hydroperoxides
Anti-inflammation : it reduces skin inflammation, which helps prevent premature ageing
Frontiers in Cellular Neuroscience 9: 298
Consequently, governments, payers, and employers are beginning to adopt these agents as core components of preventive and chronic disease management strategies, driving exponential market demand
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