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Studies have also found that adults with sleep apnea have a relatively high prevalence of depressive symptoms, and that the severity of sleep apnea positively corelated with the depressive symptoms
9, 10, Supplementary Table 2)
Novel inhibitors targeting insulin-related signal pathways, including ONC201 (AKT inhibitor), LY294002 (PI3K inhibitor), received satisfying results in preclinical studies (Fujiwara et al., 2008
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