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Tissue distribution of GLP-1R GLP-1 mediates its effects by binding to its receptor, the GLP-1R, which is a sevenfold transmembrane G-coupled receptor that increases levels of cAMP by activating adenylate cyclase (89, 95, 96)

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At its 7.2 mg dose, it produced an average weight loss of 20.7% in trials, compared with roughly 4 kg (4-5%) on Rybelsus 14 mg

Both prove that targeting multiple receptors simultaneously produces better outcomes than hitting one receptor alone