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Also helps in maintaining the body's crucial pH balance

At position 26, the lysine residue is conjugated to a C18 fatty diacid side chain via two AEEA linkers and a -glutamic acid spacer a modification that enables high-affinity reversible binding to serum albumin, creating a drug reservoir that extends the peptide's half-life to approximately one week

[2] Tramadol is conditionally recommended for treatment of osteoarthritis of the hand, knee, or hip in patients who may have contraindications to NSAIDs, find other therapies ineffective, or have no available surgical options

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