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The medication is administered via subcutaneous injection into the abdomen, thigh, or upper arm, with injection sites rotated to prevent lipodystrophy
N Engl J Med 2017;377:1327.ArticlePubMedPMC 4
Some researchers refrigerate the vial before adding water, which reduces foaming tendency
Allow the peptide to dissolve naturally over 1-2 minutes
Since tirzepatide typically produces greater weight loss (20-25% body weight versus 15-17% with semaglutide at weight loss doses), more tirzepatide users may experience telogen effluvium simply because they lost more weight faster
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