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Research has characterised MT-II-induced anorexia in rodent feeding paradigms , examining food intake suppression kinetics, meal pattern changes, body weight effects with repeated administration, and the hypothalamic neurochemical changes including NPY/AgRP suppression and melanocortin pathway activation markers accompanying MT-II-induced anorexia
10.1152/physrev.00054.2009
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This is particularly relevant as the BBB represents a major challenge in CNS drug delivery, often preventing neurotherapeutic agents from effectively reaching the brain
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