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For example, statins have a higher affinity for HMGCR, which can competitively inhibit the reduction of HMG-CoA to mevalonate, thereby reducing the amount of cholesterol synthesis
doi: 10.1056/NEJMoa2511774
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While semaglutide provides substantial metabolic benefits, its GI AEs, most notably nausea, vomiting, diarrhoea, and constipation, can compromise treatment adherence, particularly during the early dose-escalation phase
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