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Heart rate increases occurred during Retatrutide treatment, peaking at 24 weeks before declining at subsequent timepoints

Induced quiescence of Lgr5+ stem cells in intestinal organoids enables differentiation of hormone-producing enteroendocrine cells

Ceramide itself can either be generated by hydrolysis of sphingomyelin in the plasma membrane or by de novo synthesis from the amino acid serine and two fatty acids [121]