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Seiwerth, S., Brcic, L., Vuletic, L

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This effect generally resolves by reducing the dose or adjusting administration timing earlier in the evening

Key findings include: Upregulation of Shh pathway components in ischemic brain regions Enhanced neural stem cell proliferation and differentiation Improved angiogenesis supporting tissue repair Modulation of blood-brain barrier integrity The Shh pathway activation appears particularly relevant in stroke recovery models, where enhanced neurogenesis and vascular support correlate with functional improvements