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Under oxidative stress, excessive Ca 2+ influx into mitochondria exacerbates mPTP activation and m loss ( 2+ dysregulation converge to drive mitochondrial collapse, ATP depletion, and skeletal myocyte apoptosis or necrosis-ultimately contributing to the pathogenesis of muscle atrophy ( 5.2.2 Mitochondrial dysfunction exacerbates ROS production: a vicious cycle Mitochondrial dysfunction both amplifies ROS generation and impairs antioxidant defense, establishing a self-perpetuating cycle of oxidative injury and organelle deterioration (Yazdani et al., 2023)
Indian ginseng (IG) (10 mg/kg/day ginsenoside Rg3 for 21 day) is used to improve learning and memory, a nervous stimulant, and also a sexual stimulant for men [56, 78]
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Sattar N, Lee MMY, Kristensen SL, et al
