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The product is likewise indicated for increased physiologic demand (pregnancy, thyrotoxicosis, chronic hemorrhage), for drug-induced depletion, and for select neurologic or hematologic disorders in which B12 plays a pivotal metabolic role
Most commercial products (including Hospira 30 mL vials, the standard used in research) carry a 23 year expiration from manufacture
Research into predictive biomarkers could improve patient selection and treatment monitoring
Sezer, R
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