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An estimated 20% of obese patients have minimal or no response to GLP-1s and around 40% stop treatment after 12 months mostly due to shortages, dosage inconvenience3 and costs
and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins
Titration schedule: Each dose escalation occurs at four-week intervals minimum
Changes in anthropometrics For anthropometric measurements, we compared the results of reduction in BMI, body weight, BMI, WC, WHR and AG
DPP-4 inhibitors are taken orally, typically once or twice daily
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/profile/Asfandyar-Sheikh/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
