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Furthermore, the agonists of Nrf2, which serve as pivotal upstream regulators of SLC7A11, function as indirect activators of System Xc-, as they regulate SLC7A11 at the transcriptional level rather than directly modifying the functional activity of the complex (139)
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Although continuous treatment of park 13 flies with L-DOPA reduced the inherent oxidative stress consistent with previous results, the flies still showed considerably higher levels of oxidative radicals (Fig