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Vasorelaxing effects of flavonoids: investigation on the possible involvement of potassium channels

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These effects were mediated through downstream activation of transcription factors including c-Fos, c-Jun, and EGR-1, which regulate genes involved in cell cycle progression, extracellular matrix remodelling, and angiogenic signalling

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Although this review focuses on hepatotoxicity, statins can also rarely cause rhabdomyolysis and secondary kidney injury