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The nanocomposite architecture ensures sustained drug release, prolonged half-life, and enhanced tissue penetration, collectively mitigating gouty inflammation and preventing urate crystal-induced nephropathy ( Additionally, PEGdrug conjugates are prevalent functionalized carriers where PEG modifies therapeutic agents (e.g., uricase) to improve pharmacokinetics and reduce immunogenicity (Ozer et al., 2022)
& Iwasaki, A
Microorganisms 8:784
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