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GluK1-GluK3 are low affinity KAR subunits, due to relatively high concentration of agonist needed for their activation (K D for [ 3 H]kainate, 50100 nM) compared to GluK4 and GluK5 which are high affinity subunits (K D for [ 3 H]kainate, 5 nM) (Figure 1B)
How these two effects interact when combined has not been studied, so the net effect on blood sugar is unknown
doi: 10.3390/v13112132 131 KaklamanosA.BelogiannisK.SkendrosP.GorgoulisV
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