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Our literature search identified one prior systematic review and meta-analysis with tirzepatide that included four RCTs (2783 participants) [26]

DSIPs effect, while significant, was less pronounced than that of DSIP-CBBBP

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Yet, more recently, a metabolomic analysis reveals the importance of glutamine uptake by ASCT2 and its conversion into ROS-producing intermediate metabolite -Ketoglutarate as marker of sensitivity during sulfasalazine xCT-inhibition cell death in head and neck squamous cells carcinoma (46)