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Potential Withdrawal Symptoms Discontinuing tirzepatide can result in withdrawal symptoms due to its effects on blood sugar regulation and appetite control
Thus, since several mutations affecting the functional domains of p62 have been identified in patients with ALS and frontotemporal dementia, it has been demonstrated that p62 variants exhibit reduced KEAP1-binding, preventing NRF2 from entering the nucleus and promoting protective genes, and predisposing the cell death upon exposure to ROS [250, 251]
This is very crucial given the dynamic nature of therapies involving peptides
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