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Reductions of up to approximately 10% were observed in certain biomarkers, although these effects did not translate into measurable clinical benefit within the trial timeframe

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In data comparing results from weeks 1-4 and 5-8 (with semaglutide dose doubling from 0.25mg/week to 0.5mg/week over that interval) a clear dose-sensitivity was seen in most measures: the beneficial impacts of the medication (measured by effect size) were greater at the higher dose

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