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Eli Lilly submitted the orforglipron NDA to the FDA in Q1 2026 following ATTAIN Phase 3 trial data showing 14.7% body weight reduction at 45mg positioning the worlds first oral small molecule GLP-1 receptor agonist for obesity for anticipated FDA approval in late 2026 or 2027
The coefficient of variation for qPCR-based telomere assays runs between 5 and 12% depending on the laboratory, as documented in a methods comparison published in PLOS ONE 7
Enalapril Enalapril is a rather common anti-hypertensive medication, and it has been reported to inhibit fibroblasts proliferation and HA production in cheloid scars (59, 60)
It remains however to be proven to which extent these described mechanisms are related to the modest blood pressure decrease observed in humans and whether they contribute to stroke prevention
Researchers are actively studying the potential for GLP-1s to help with other health concerns including aspects of brain health something McIntyre says hes excited about
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