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At 4,114 Daltons (semaglutide) and 4,813 Daltons (tirzepatide), GLP-1 agonists are 8 to 10 times larger than the typical threshold for easy milk transfer

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For example, 5-lipoxygenase (5-LOX) inhibitor zileuton inhibits glutamate toxicity and ferroptosis by inhibiting cytoplasmic ROS production in HT22 cells, thereby exerting neuroprotective effects (Liu et al., 2015)