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Doxorubicin was selected as a training compound for three reasons: i) the quinone moiety, present in doxorubicin, is acknowledged as a notorious redox cycler
Sources: Hill RA, Hunter RA, Lindsay DB, Owens PC
Side effects are mainly seen with IV glutathione and include potential damage to kidneys, liver & thyroid
Trp53 fl/fl ) as previously described 20,91 3 days post i.p
Kovacs D, Cardinali G, Picardo M, Bastonini E
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