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In a 2013 study by Korenevsky et al., the researchers administered a combination of melatonin and epithalon to female rats exposed to suboptimal environmental factors, such as light pollution, finding that the combined therapy rectified various impairments of the hypothalamic-pituitary-gonadal axis [13]

Research has investigated its interactions with nitric oxide (NO) pathways, growth factor modulation (including VEGF and EGF), and the FAK-paxillin signaling cascade involved in tissue remodeling studies

To minimize the impact of nonspecific stress stimuli on the experimental animals, they should be handled for 12 min daily before the experiment

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