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doi: 10.1007/s11154-014-9288-6 59 Martin-GallausiauxCMarinelliLBlottireHMLarraufiePLapaqueN
During anaplerosis, mitochondrial glutamate dehydrogenase 1 (GLUD1) plays a key role by catalyzing the conversion of glutamate to alpha-ketoglutarate (-KG) and releasing ammonia, which regulates autophagy and neutralizes the intracellular pH in cancer cells 19,20
Outro mecanismo envolvido na depleo das clulas T seria uma maior produo de ceramida, protena que age como mediador endgeno de apoptose em algumas linhas celulares e provoca aumento na replicao do HIV-1
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