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As fat tissue grows and more NNMT is produced, higher amounts of hormones and pro-inflammatory signals are produced that are responsible for weight gain and other chronic diseases such as type 2 diabetes and cardiovascular disease. NNMT is responsible for converting nicotinamide (NA) into 1-methylnicotinamide (1-MNA), which takes it out of the NAD salvage pathway (see the diagram below)

This substitution may improve the peptides resistance to enzymatic degradation and enhance its stability

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The medication requires once-weekly subcutaneous administration and delivers consistent appetite control alongside blood sugar regulation

NNMT Inhibitors as a Therapeutic Option for Metabolic Disorders. Journal of Medicinal Chemistry Policarpo, R., et al