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Altered daytime fluctuation pattern of plasminogen activator inhibitor 1 in type 2 diabetes patients with coronary artery disease: a strong association with persistently elevated plasma insulin, increased insulin resistance, and abdominal obesity
These effects typically improve within the first 2-3 weeks at each dose
This doesnt mean you need years of failed diets, but some documented effort demonstrates that youve tried and that pharmaceutical support is warranted rather than a first-line approach
for example, SURPASS 1 included treatment of nave patients, whereas others included patients on different oral anti-diabetic agents (metformin, sulfonylurea, pioglitazone, SGLT-2 inhibitor, and/or insulin)
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