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doi: 10.1002/ijc.33871 191 LiuGBiYShenBYangHZhangYWangXet al

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When ibuprofen is necessary , several strategies can minimise risks: Take with food reduces direct gastric irritation, though Wegovy slows digestion Use the lowest effective dose typically 200-400mg for mild to moderate pain Limit duration avoid prolonged courses without medical supervision Stay well-hydrated particularly important given Wegovy's gastrointestinal effects Consider gastric protection proton pump inhibitors (PPIs) may be appropriate for extended NSAID use if recommended by a clinician based on your risk factors For over-the-counter use, ibuprofen should typically not exceed 1.2g per day (e.g., 400mg three times daily) unless advised by a healthcare professional

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### Regulatory Status and Availability **AOD-9604:** - Never received FDA approval for any indication - Classified by the FDA as a **Category 2 bulk drug substance** not eligible for compounding under Section 503B - Removed from many international peptide supplier platforms (including Alibaba and related marketplaces) - Legal status varies by country

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