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Gut microbiota-tryptophan Metabolism-GLP-1 axis participates in beta-cell regeneration induced by Dapagliflozin

Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways

Frequent use of antibiotics Higher levels of radiation therapy and X-rays Pesticides and herbicides Cleaning chemicals in conventional household products (laundry powders, dishwashing powders, air fresheners, mothballs, bleach) Nitrates and other food preservatives (especially food like salami, hams or other cured and processed meats) Smoking Alcohol consumption Poor diet Light pollution at night (E.g., light from mobile phones and street lights suppress melatonin production at night and in turn, glutathione levels.) Signs of glutathione deficiency: Brain fogginess Tiredness Joint stiffness Dry skin Restlessness Low mood Coming down with ills and chills more often Foods that help our natural GSH production Sulphur rich, cruciferous vegetables including broccoli, Brussels sprouts, cauliflower, cabbage, kale, watercress, radish and turnips

Caspase-3 is known to be activated by ROS [54, 78] and promote PS externalization in eryptosis [135, 136]

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