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Targeting macrophage polarization has emerged as a promising therapeutic strategy for diabetic complications
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(1998) identified the first GPCR heterodimer and described it as an obligate heterodimer, consisting of the complex formed by a GABA B R1 and a GABA B R2 protomer (Jones et al., 1998
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The glutamate residue is linked through its side-chain carboxyl, giving a gamma-glutamyl bond rather than a standard alpha-peptide bond, which is why the molecule resists most intracellular peptidases and is cleaved chiefly by gamma-glutamyl transpeptidase at the cell surface
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