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Those taking the placebo (an injection with no medication in it) only had an average of 3% (about 7 lbs) weight loss

Compared to placebo, low certainty evidence show that L-carnitine supplementation significantly changes (reduced) more in AST levels and ALT levels (MD: 26.38, 95%CI: 45.46 to 7.30), and moderate certainty evidence show that L-carnitine supplementation significantly changes (reduced) more in HDL cholesterol levels (MD: 1.14, 95%CI: 0.21 to 2.07) and triglyceride levels (MD: 6.92, 95%CI: 13.82 to 0.03)

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Buckley ST, Schele SG, Kirk RK, Knudsen LB

Tirzepatide (dual hormone action) may lead to slightly higher weight loss, while Semaglutide (single hormone) has a longer track record and multiple dosing options