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When GLP-1 reaches the pancreas, it binds to GLP-1 receptors (GLP-1R) expressed on the pancreatic cells, stimulating insulin release
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Emerging data mostly acquired from the CVOTs conducted for the various GLP-1 receptor agonists now available, also suggest that they may offer renoprotection [8]
Notably, these improvements occurred early in treatment and persisted throughout the study duration
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