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Once you reach your goal weight, something shifts

We hypothesize that the failure of intrinsic-solubility approaches arises from inaccuracies in the predicted valuesalthough Starling is a state-of-the-art p K a -prediction model, it still routinely predicts values that are wrong by 0.51.0 p K a unit, which can correspond to a 10x difference in the predicted value

Results still clinically significant, just potentially in lower range of expectations

But if its, for example, you had surgery after you were already, like you had gut issues since you were a teenager and your surgery was in your 20s, then Im not going to think that that surgery scar tissue is, its definitely not the only root cause because you had those issues prior

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